1965;9(3):127-136. View abstract. View abstract. Researchers from another review concluded that ashwagandha might be useful in conditions such as: Studies used in this review included human, animal, and lab research. Vitamin D supplementation improves anxiety but not depression symptoms in patients with vitamin D deficiency. View abstract. If you have blood sugar problems, keep hard candies, glucose tablets, liquid glucose, or juice on hand for low blood sugar. J Ayurveda Integr Med. View abstract. Mishra LC, Singh BB, Dagenais S. Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. This dosing has also been associated with improvements in memory. View abstract. Levothyroxine is used to treat the following conditions: Hashimoto's disease. Kulkarni, S. K. and Dhir, A. Withania somnifera: an Indian ginseng. It also covers possible side effects of the herb, interactions, dosage information, and guidance regarding selecting ashwagandha supplements. 2022;15(9):1067-1080. doi:10.1080/17512433.2022.2121699, Salve J, Pate S, Debnath K, Langade D. Adaptogenic and anxiolytic effects of Ashwagandha root extract in healthy adults: a double-blind, randomized, placebo-controlled clinical study. Sriranjini SJ, Pal PK, Devidas KV, Ganpathy S. Improvement of balance in progressive degenerative cerebellar ataxias after Ayurvedic therapy: a preliminary report. Withania somnifera, known as ashwagandha, has a role in ayurvedic medicine for a wide range of health conditions. Dasgupta A, Peterson A, Wells A, Actor JK. Those who took 600 milligrams per day of ashwagandha had better results than those in the 250 milligrams per day group, yet both groups saw improvements in stress. Skinmed. Chauhan S, Srivastava MK, Pathak AK. There are a variety of vitamins and minerals that are essential for good health. A recent study out of India compared varying doses of ashwagandha to a placebo for the treatment of stress. Indian J Exp Biol. Indian J Exp Biol 1997;35:236-9. There is little evidence for its use as an "adaptogen." Ashwagandha contains chemicals that might help calm the brain, reduce swelling, lower blood pressure, and alter the immune system. Go to the ER right away. This information does not endorse any treatments or medications as safe, effective, or approved for treating a specific patient. There is no scientific evidence to support one supplement form over another, which means you should choose the one that best fits your lifestyle. root extract in improving cardiorespiratory endurance and recovery in healthy athletic adults. J.Transl.Med. Sud Khyati S, Thaker B. View abstract. There is little evidence for its use as an "adaptogen." Ashwagandha contains chemicals that. These side effects may be mild or severe. This is according to a recent review of case studies of liver damage caused by ashwagandha. Withania somnifera extract. View abstract. Animal research and one case study indicate that the herb might increase serum concentration of thyroid hormones, according to Ray Sahelian, a medical doctor who specializes in natural supplements. Ashwagandha might cause sleepiness and drowsiness. Can You Take A Z-Pak If You Have A Penicillin Allergy? Some of these interactions can be life-threatening. View abstract. Ashwagandha is thought to have a positive impact on chronic stress. Significant improvements were seen in all sleep parameters for those who took ashwagandha (300 milligrams twice daily). For more information, read the "What else do I need to know?" section below. It's best to talk to your doctor before you start taking antidepressants and vitamins, especially mixed supplements. Assessment of Withania somnifera root extract efficacy in patients with generalized anxiety disorder: A randomized double-blind placebo-controlled trial. Cookies collect information about your preferences and your devices and are used to make the site work as you expect it to, to understand how you interact with the site, and to show advertisements that are targeted to your interests. Copyright 2023 UpToDate, Inc. and its affiliates and/or licensors. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Cancer Lett 2000;148:9-17. 2023 Dotdash Media, Inc. All rights reserved, Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Cureus. Insomnia is a common sleep disorder that is defined as an inability to get adequate sleep. Be aware that antidepressants and vitamins typically work with each other the vitamins won't replace your medication. These supplements may contain similar active ingredients or have potential uses that are like those of ashwagandha. Also learn why ingredients such as alpha-lipoic acid, soy, resveratrol, quercetin may impair thyroid function. The specific components of physical performance included strength and power, endurance, and fatigue/recovery. Ashwagandha can react with certain medications and supplements you may already take, and result in adverse effects. Read our. Taking high doses of ashwagandha may increase your risk of side effects. Indian J Psychol Med. 2011;68(1):3-8. Headache. Ashwagandha side effects. Ashwagandha contains several active constituents including: The mechanism of how ashwagandha works, for all of its purported benefits, is not well understood. Am J Ther 2023;30(1):e80-e83. PLoS One 2009;4:e6628. It should not be confused with Physalis alkekengi, which is also referred to as winter cherry. Choudhary, M. I., Nawaz, S. A., ul-Haq, Z., Lodhi, M. A., Ghayur, M. N., Jalil, S., Riaz, N., Yousuf, S., Malik, A., Gilani, A. H., and ur-Rahman, A. Withanolides, a new class of natural cholinesterase inhibitors with calcium antagonistic properties. Therefore, before using this product, tell your doctor or pharmacist of all the . Anbalagan, K. and Sadique, J. J Pharm Pharmacol 1998;50:1065-68. Malviya, N., Jain, S., Gupta, V. B., and Vyas, S. Recent studies on aphrodisiac herbs for the management of male sexual dysfunction--a review. This interference is likely due to a similarity in chemical structure, according to Drugs.com. However, if you were to combine St. John's wort with antidepressants like SSRIs, you could end up with disastrous results. A total of 525 drugs are known to interact with Xanax. Most ashwagandha supplements are naturally vegan and gluten-free. Diarrhea. View abstract. 2020;12(4):1119. Liver Int. J Altern Complement Med. Herbal supplements can strongly affect the body. This article provides a review of the potential uses of ashwagandha. Ashwagandha-induced liver injury: a case series from Iceland and the US Drug-Induced Liver Injury Network. Withania somnifera, known as ashwagandha, has a role in ayurvedic medicine for a wide range of health conditions. Thank you, {{form.email}}, for signing up. Effect of Indian Ayurvedic medicine Ashwagandha on measurement of serum digoxin and 11 commonly monitored drugs using immunoassays: study of protein binding and interaction with Digibind. Nutrients. J Clin Med 2021;10(16):3644. If you consume something that isn't recommended, you could end up reducing the effectiveness of your medication or increasing the likelihood of side effects. These side effects are usually experienced on higher doses. Ahumada F, Aspee F, Wikman G, and et al. It is not meant to be comprehensive and should be used as a tool to help the user understand and/or assess potential diagnostic and treatment options. Salve J, Pate S, Debnath K, Langade D. Adaptogenic and anxiolytic effects of ashwagandha root extract in healthy adults: A double-blind, randomized, placebo-controlled clinical study. Another traditional use of ashwagandha in Ayurveda is for memory issues. Ireland PJ, Hardy T, Burt AD, Donnelly MC. Large-scale studies are necessary to prove ashwagandha's effects on stress further. By Mayo Clinic Staff Herbal supplements are natural, so they must be safe, right? Bull Natl Res Cent. View abstract. These medications work in the brain by indirectly enhancing the action of a chemical in the brain called gamma-aminobutyric acid (GABA) a neurotransmitter that has a calming effect which helps lower anxiety levels. Supplements That Are Similar to Ashwagandha. Dhuley, J. N. Effect of ashwagandha on lipid peroxidation in stress-induced animals. Vitamin Keven in foods such as kale, lettuce, broccoli, and chickpeascan counteract a blood thinner's benefits. Ven Murthy, M. R., Ranjekar, P. K., Ramassamy, C., and Deshpande, M. Scientific basis for the use of Indian ayurvedic medicinal plants in the treatment of neurodegenerative disorders: ashwagandha. Ashwagandha might lower blood pressure. A systematic review and meta-analysis of randomized controlled trials. View abstract. These severity listings are for informational use only. Drug Metabol.Drug Interact. Be sure to tell your doctor if you are breastfeeding. 2004;42(12):2015-2020. Usually ashwagandha is taken 1000 mg per day, for the course of 3 to 4 months. According to an August 2016 study in the Complementary Therapies in Medicine Journal, taking ashwagandha with antidepressants like SSRIs can be a safe, effective and healthy way of supporting your mental health. 2021;2021:8254344. doi:10.1155/2021/8254344, Choudhary D, Bhattacharyya S, Bose S. Efficacy and Safety of Ashwagandha (Withania somnifera (L.) Dunal) root extract in improving memory and cognitive functions. View abstract. Efficacy and safety evaluation of ayurvedic treatment (ashwagandha powder and sidh makardhwaj) in rheumatoid arthritis patients: a pilot perspective study. Ashwagandha - More Interactions. Do note that ashwagandha itself does not . View abstract. Ashwagandha and other dietary supplements should never replace standard medicine or care. Naturopathic care for anxiety: a randomized controlled trial ISRC TN78958974. Journal of Research in Ayurveda and Siddha 1980;1(2):247-258. Sometimes, these supplements are stand-alone products or multivitamins; in other cases, they are mixed in with healthy food products, like spirulina, chlorella or herbal products. Ashwagandha's cortisol-lowering effects may be responsible. The best time to take ashwagandha is at the time that works best for you. There is concern that ashwagandha interacts with anesthesia commonly used in surgery. I was told that I had an allergic reaction to penicillin when I was a child. J Neurol Sci 2000;176:124-7. Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. 1998;60(2):173-178. Select a condition to view a list of vitamins. Cheah KL, Norhayati MN, Husniati Yaacob L, Abdul Rahman R. Effect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis. Speak with a, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Mediterranean, Low-Fat Diets Are Best for Heart Problems, Least Amount of Exercise You Need to Stay Healthy, Nerve 'Pulse' Therapy May Help Ease Sciatica, New Book: Take Control of Your Heart Disease Risk, MINOCA: The Heart Attack You Didnt See Coming, Health News and Information, Delivered to Your Inbox, Attention deficit-hyperactivity disorder (ADHD), Chronic obstructive pulmonary disease (COPD), Antipsychotic-induced metabolic side effects, Think Your Child Has ADHD? Essential vitamins, minerals and amino acids that are involved in neurobiological function include: However, several of these have had mixed results in helping support depression treatment. She founded the Fad Free Nutrition Blog and Nutricion al Grano websites and is based in Texas. Ashwagandha may increase thyroid hormone levels. Several supplements and herbs may act similarly to ashwagandha. Venkataraghavan S, Seshadri C, Sundaresan TP, and et al. Ultimately, the supplements and foods you can . It may also interact with other herbs, supplements, and even foods. ashwaganda: Dosing, contraindications, side effects, and pill pictures - epocrates online Drug Lookup: Browse: Drugs Alt Meds Select a medication above to begin. IV. The plan to ashwagandha blood pressure medication interaction enter the company was does blood pressure medication make you put on weight quietly implemented the one from Hebei do hypertension medications affect sexuality University has already started the procedure the Yinchuan University s Zhou Qitian also agreed, and the next step is to do the school work Inner Mongolia can probiotics lower . 1965;9(1):9-15. Indian J Exp Biol. You may think that these supplements are safe because they also have antidepressant effects, but it's not that simple. 2021;51(4):363-365. The combination could result in excess thyroid hormone in the body, which has many negative effects. 2013;2013:571420. 1981;19(3):245-249. 4. View abstract. Khattak, S., Saeed, Ur Rehman, Shah, H. U., Khan, T., and Ahmad, M. In vitro enzyme inhibition activities of crude ethanolic extracts derived from medicinal plants of Pakistan. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. Chitre D, Nadkarni S, Jagtap N, et al. Ashwagandha may interact with various medications. Many of the studies on ashwagandha have been performed in laboratory settings or on animal models, but some human trials do exist. Ashwagandha has no known moderate interactions with any drugs. Be sure to tell your doctor that you take this product if you are scheduled for surgery or tests. Agnihotri AP, Sontakke SD, Thawani VR, Saoji A, Goswami VS. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat. Since the effects of grapefruit juice may last as long as 3 days, it should be avoided if you are taking atorvastatin (Lipitor), lovastatin (Mevacor, Altoprev) or simvastatin (Zocor). Clinical Evaluation of the Spermatogenic Activity of the Root Extract of Ashwagandha (Withania somnifera) in Oligospermic Males: A Pilot Study. Some other sedative medications include clonazepam (Klonopin), lorazepam (Ativan), phenobarbital (Donnatal), zolpidem (Ambien), and others. View abstract. Gupta, S. K., Dua, A., and Vohra, B. P. Withania somnifera (Ashwagandha) attenuates antioxidant defense in aged spinal cord and inhibits copper induced lipid peroxidation and protein oxidative modifications. Monitor your blood sugar closely. Prog.Neuropsychopharmacol.Biol.Psychiatry 7-1-2008;32(5):1093-1105. 2020;12(2):e7083. Last updated Apr 30, 2023 Key points Ashwagandha has not been well studied in regard to potential interactions with prescription medication. View abstract. Ashwagandha is not naturally found in foods, which means the only way to get it is through supplements. losartan, valsartan, telmisartan), Beta-Blockers (e.g. I have it on my medical HelloPharmacist Similar results were reported in another study that examined ashwagandha's effect on attaining quality sleep. 8-19-2005;334(1):276-287. 8 Warning Signs of Depression You Shouldn't Ignore, Depression in Adults With a Chronic Physical Health Problem: Treatment and Management, How Vegans Can Get All Their Nutrients (Without Taking Supplements), Complementary Therapies in Medicine Journal, 15 Celebrities Who Struggle With Anxiety and Depression, Australian Journal of Herbal Medicine: "B Vitamins Enhance Antidepressant Response in Adults", Open Neurology Journal: "Vitamin B12 Supplementation in Treating Major Depressive Disorder: A Randomized Controlled Trial", Journal of Psychiatry: "Adjunctive Nutraceuticals for Depression: A Systematic Review and Meta-Analyses", Mayo Clinic: "MAOIs and Diet: Is It Necessary to Restrict Tyramine? Curr Clin Pharmacol. Upton R, ed. Agarwal R, Diwanay S, Patki P, Patwardhan B. Praveenkumar, V., Kuttan, R., and Kuttan, G. Chemoprotective action of Rasayanas against cyclosphamide toxicity. Nevertheless, be sure to talk to your doctor before adding on ashwagandha to blood pressure medicine, such as: Ashwagandha might increase the effects and adverse effects of thyroid hormone drugs. It is not intended to be medical advice or a substitute for the medical advice, diagnosis, or treatment of a health care provider based on the health care provider's examination and assessment of a patients specific and unique circumstances. When you visit the site, Dotdash Meredith and its partners may store or retrieve information on your browser, mostly in the form of cookies. Ashwagandha may interact with certain drugs by enhancing or negating their actions. doi:10.1097/MD.0000000000017186, Pratte MA, Nanavati KB, Young V, Morley CP. 1998;20(1):191-198. Effect of Asian ginseng, Siberian ginseng, and Indian ayurvedic medicine Ashwagandha on serum digoxin measurement by Digoxin III, a new digoxin immunoassay. Sharma AK, Basu I, Singh S. Efficacy and safety of Ashwagandha root extract in subclinical hypothyroid patients: a double-blind, randomized placebo-controlled trial. Effects of Withania somnifera in patients of schizophrenia: a randomized, double blind, placebo controlled pilot trial study. Changes in thyroid hormone concentrations after administration of ashwagandha root extract to adult male mice. 9-1-2010;10(3):238-246. Ashwagandha interacts with several types of prescription medicine, so consult your health care provider before taking this herbal remedy. If you take thyroid medicine, consult your doctor before using ashwagandha. How to use To use ashwagandha products safely, people must always follow the dosage advice given by the manufacturer. No supplement is intended to treat, cure, or prevent disease. Withania somnifera, also commonly as ashwagandha or winter cherry, is a shrub native to parts of Asia and Africa. 8-16-1995;95(1-2):189-193. Taking ashwagandha along with sedative medications might cause too much sleepiness. Created for people with ongoing healthcare needs but benefits everyone. Lower ashwagandha doses of 225 milligrams per day to 400 milligrams per day have been associated with perceived improvements in stress and anxiety. This can result in serotonin syndrome, which causes side effects like anxiety, sweating, confusion, tremors, lack of coordination and an accelerated heart rate. Never start, stop or otherwise change your therapy before speaking with your provider. View abstract. View abstract. Hi, I was recommended to take ashwagandha. However, tyramine-rich foods like cheeses, beer and other fermented products are dangerous for people taking MAOIs. Notably, ashwagandha doses typically do not exceed 1,000 milligrams per day for up to 12 weeks. Ashwagandha has been traditionally used for anxiety, insomnia, aging, and other conditions that may be exacerbated by stress. Therefore, it is recommended to consult with a healthcare professional before adding ashwagandha to a weight loss plan, especially if you have any underlying medical conditions or are taking any medications . No, that's not true all the time. I am wondering if it is okay to take with my prescriptions. Taking it with drugs that increase levels of thyroid hormone (e.g. Per the research, ashwagandha demonstrated small but significant benefits on overall sleep for those with insomnia. View abstract. Phase III randomized clinical trial of BV-4051, an Ayurvedic polyherbal formulation in moderate SARS-CoV-2 infections and its impact on inflammatory biomarkers. The roots can be used topically as a poult. If you're taking antidepressants and vitamins at the same time, be aware of the ingredients in your vitamin supplements. 2021;57:102642. doi:10.1016/j.ctim.2020.102642, Bjrnsson HK, Bjrnsson ES, Avula B, et al. Now, most studies suggest that ashwagandha doesn't have significant blood pressure lowering effects, so the interaction here is thought to be relatively mild. 2021 Nov 25;13(2):100510. Tumori 8-31-1994;80(4):306-308. 2016;928:329-373. doi:10.1007/978-3-319-41334-1_14. This can result in serotonin syndrome, which causes side effects like anxiety, sweating, confusion, tremors, lack of coordination and an accelerated heart rate. J Diet Suppl. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. 2019;98(37):e17186. The comparative effect of milk fortified with Aswagandha, Aswagandha and Punarnava in children - a double-blind study. A double-blind, randomized, placebo-controlled trial on the effect of Ashwagandha (Withania somnifera dunal.) What Happens If I Take Too Much Ashwagandha? Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study. blood glucose). As an adaptogen, helping the body resist physiological and psychological stress, Steroidal lactones (withanolides, withaferins), GLP-1 Agonists (e.g. Ajgaonkar A, Jain M, Debnath K. Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract for Improvement of Sexual Health in Healthy Women: A Prospective, Randomized, Placebo-Controlled Study. Ashwagandha has no known moderate interactions with any drugs. Therefore, it is important to talk to your healthcare provider about any supplements you plan to take and check in about potential interactions with other supplements or medications. Indian J Exp Biol 2000;38:607-9. Hypothyroidism, After Thyroid Removal. However, some other statins do not seem to be affected by grapefruit juice, including pravastatin (Pravachol), fluvastatin (Lescol) and rosuvastatin (Crestor). 2021;18(2):183-226. doi:10.1080/19390211.2020.1741484, D'Cruz M, Andrade C. Potential clinical applications of Ashwagandha (Withania somnifera) in medicine and neuropsychiatry. Tohda, C. [Overcoming several neurodegenerative diseases by traditional medicines: the development of therapeutic medicines and unraveling pathophysiological mechanisms]. Prez-Gmez J, Villafaina S, Adsuar JC, Merellano-Navarro E, Collado-Mateo D. Effects of ashwagandha (Withania somnifera) on VO2max: A systematic review and meta-analysis. Always talk with a healthcare provider before starting any new supplement regimen. Pharmacol Biochem.Behav 2003;75(3):547-555. View abstract. Medically reviewed by Drugs.com. First and foremost, I want to point out this it can tricky to determine whether or not a dietary/herbal supplement will interact with prescription drugs due to a general lack of studies on the matter. J Ethnopharmacol 1999;64:91-3. Dongre S, Langade D, Bhattacharyya S. Efficacy and safety of ashwagandha (withania somnifera) root extract in improving sexual function in women: a pilot study. In our latest question and answer, the pharmacist discusses whether or not ashwagandha supplements interact with prescription drugs. Indian J Exp Biol. Be sure to talk with your doctor about this and all drugs you are taking, especially digoxin. Third-party agencies like these confirm that supplements actually contain what they say they do, but they do not approve medical claims. 2021;272:113929. doi:10.1016/j.jep.2021.113929, Bonilla DA, Moreno Y, Gho C, Petro JL, Odriozola-Martnez A, Kreider RB. What to Look for When Choosing Ashwagandha Supplements, Uses of Lavender: Everything You Need to Know, I Tried Taking Ashwagandha and It Gave Me Crazy Vivid Dreams, Natural withanolides in the treatment of chronic diseases, Pharmacological evaluation of ashwagandha highlighting its healthcare claims, safety, and toxicity aspects, Potential clinical applications of Ashwagandha (, Adaptogenic and anxiolytic effects of Ashwagandha root extract in healthy adults: a double-blind, randomized, placebo-controlled clinical study, An investigation into the stress-relieving and pharmacological actions of an ashwagandha (, An alternative treatment for anxiety: a systematic review of human trial results reported for the Ayurvedic herb ashwagandha (, Efficacy and safety of Ashwagandha root extract on cognitive functions in healthy, stressed adults: a randomized, double-blind, placebo-controlled study, A double-blind, randomized, placebo-controlled trial on the effect of Ashwagandha (, Safety of ashwagandha root extract: a randomized, placebo-controlled, study in healthy volunteers, Ashwagandha-induced liver injury: a case series from Iceland and the US Drug-Induced Liver Injury Network, DNA damage by withanone as a potential cause of liver toxicity observed for herbal products of, Effects of L-Theanine administration on stress-related symptoms and cognitive functions in healthy adults: a randomized controlled trial, Vitamin D supplementation improves anxiety but not depression symptoms in patients with vitamin D deficiency, Vitamin E, turmeric and saffron in treatment of Alzheimer's disease, Tart cherry juice in athletes: a literature review and commentary, Dietary supplements: what you need to know.
does ashwagandha interact with medications
does ashwagandha interact with medications
does ashwagandha interact with medications