The treated skin is washed and gently scrubbed to remove loose skin and scabs. Fluorouracil cream should not be applied on the eyelids or directly into the eyes, nose, or mouth because irritation may occur. de Andrade, G.L. Dietrich, P.; Hellerbrand, C. Non-Alcoholic Fatty Liver Disease, Obesity and the Metabolic Syndrome. It should be noted that a limitation of this study is the sample size. Treatment for actinic keratoses is continued for 2 to 4 weeks. ; Vos, W.; Bloemena, E.; Wouters, D.; van Riel, J.M.G.H. This site needs JavaScript to work properly. Accessibility Intraepidermal carcinoma ulcerating after 3 weeks' treatment, Mild reaction after 10 days treatment to keratoses, Intraepidermal carcinoma ulcerating after 3 weeks' treatment. government site. articles published under an open access Creative Common CC BY license, any part of the article may be reused without Clipboard, Search History, and several other advanced features are temporarily unavailable. With isolated, easily accessible basal cell carcinomas, surgery is preferred since success with such lesions is almost 100%. Find support for a specific problem in the support section of our website. Suite 210-B, Inflammation and histopathological alterations were also detected. The widely reported adverse effects are infusion reactions, rash, fever, nausea, vomiting, peripheral neuropathy, and hepatic injury. Pharmacogenomics of 5-Fluorouracil in Colorectal Cancer: Review and Update. Curated list of tags to add to your discussions Intas Pharmaceuticals Limited, Side Effects. Tell your doctor if any of these symptoms are severe or do not go away: loss of appetite nausea unusual tiredness or weakness dizziness headache hair loss dry and cracked skin vision changes eye that are teary or sensitive to light redness, pain, swelling, or burning at the site where the injection was given ; Hijona, L.; Macarulla, M.T. An official website of the United States government. If any unusual or severe reaction occurs, stop applying it and contact your health professional. ; Shang, J.Y. Measurements were performed in 80 distal and 80 proximal tubules per animal. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. ; Maifrino, L.B.M. 5-FU produces histological changes in the three organs analyzed, causes physiological alterations in the liver and kidneys, and promotes oxidative stress and inflammation in the liver and lungs. ; Reijnders, D.; Safarikova, B.; Jelinkova, I.; Grandien, A.; Hyrslova Vaculova, A.; Zhivotovsky, B.; Olsson, M. 5-Fluorouracil-Induced RNA Stress Engages a TRAIL-DISC-Dependent Apoptosis Axis Facilitated by P53. About 10 to 20 g of 5-FU is used for each limb. It can be recommenced if necessary. Sharma, V.; Gupta, S.K. After you have been instructed to stop using the fluorouracil cream, you may be prescribed a specific moisturiser or mild topical steroid< to help to heal the treated area. The prepared hydrogels were characterized by SEM Gastrointestinal: Medicinal taste, stomatitis. ; Khaw, P.T. Hardy, T.; Oakley, F.; Anstee, Q.M. This quantification was performed in relation to the number of foci per area (lower magnification) of the histological tissue. Accord Healthcare Inc. FOR TOPICAL USE ONLY Medication should be continued until the inflammatory response reaches the erosion stage, at which time use of the drug should be terminated. Ozer, J.; Ratner, M.; Shaw, M.; Bailey, W.; Schomaker, S. The Current State of Serum Biomarkers of Hepatotoxicity. Other side effects of fluorouracil include: Chest pain ( angina) Coronary arteriosclerosis Thrombophlebitis Darkening of veins Gastrointestinal ulcer Increased alkaline phosphatase Increased liver function tests (LFTs) Hyperbilirubinemia Hypercholesterolemia (increased LDH) Severe allergic reaction ( anaphylaxis) If you have any concerns with your skin or its treatment, see a dermatologist for advice. The incidence and mortality rates of cancer continue to rise globally, with an estimated 19.3 million new cases and 10 million deaths in 2020 [, The mechanism of action of 5-FU depends on anabolic reactions (synthesis) that generate active metabolites: fluoro-deoxyuridine monophosphate (FdUMP), fluorodeoxyuridine triphosphate (FdUTP), and fluorouridine triphosphate (FUTP) [, As a chemotherapeutic agent, the action of 5-FU presents a systemic effect, i.e., healthy tissue cells are also affected by the 5-FU toxicity [, To alleviate the side effects, the administration of the chemotherapeutics agent needs to be carried out with adequate dosage in periodic cycles, to allow healthy tissues to recover [. Fluorouracil Additionally, cases of miscarriage and a birth defect (ventricular septal defect) have been reported when fluorouracil cream was applied to mucous membrane areas during pregnancy. New Zealand approved datasheets are the official source of information for these prescription medicines, including approved uses and risk information. 14C-labeled fluorouracil. Brunt, E.M. Nonalcoholic Steatohepatitis. 5 DPD enzyme deficiency can result in shunting of fluorouracil to the anabolic pathway, leading to cytotoxic activity and potential toxicities. ; Basnakian, A.G. Tunel Assay: A Powerful Tool for Kidney Injury Evaluation. . Follow-up biopsies should be performed as indicated in the management of superficial basal cell carcinoma. World Health Organization (WHO). ; Lv, X.F. Coronado-Cerda, E.E. A Rodent Model of Human-Dose-Equivalent 5 These pathological processes might be induced by the oxidative stress and inflammation resulting from 5-FU chemotherapy [ 27, 28, 29, 30 ]. The apoptosis rate was evaluated in histological sections obtained from segments of the square lobe of the liver, the right kidney, and the left lung. Fluorouracil administered parenterally has been shown to be teratogenic in mice, rats, and hamsters when given at doses equivalent to the usual human intravenous dose; however, the amount of fluorouracil absorbed systemically after topical administration to actinic keratoses is minimal (see Eighty-eight lesions treated with the cream produced 7 failures. Clinical treatment with 5-FU did not promote inflammatory or oxidative alterations in the kidney samples; however, histological and biochemical changes were observed, including increased serum urea and uric acid. Protective Effect of Plumeria Pudica Latex Proteins on Intestinal Mucositis Induced by 5-Fluorouracil. Carcinogenesis, Mutagenesis, Impairment of Fertility: 40 g in 1 TUBE; Type 0: Not a Combination Product, manufacture(16729-542) , analysis(16729-542). Special Senses: Conjunctival reaction, corneal reaction, lacrimation, nasal irritation. 5-Fluorouracil; GI cancer; Neuroendocrine tumor; Neurotoxicity; Stroke mimic. Cardiol J. Feature papers represent the most advanced research with significant potential for high impact in the field. MDPI and/or Set id: 667d4059-de90-4d3f-86c2-c2573def2ecb. Kuan, H.Y. doi: 10.1016/j.currproblcancer.2021.100746. People using this drug may get skin reactions where this drug is used. Effects of fluorouracil cream applied to actinic keratoses ; Rovere-Querini, P.; Manfredi, A.A. 5-Fluorouracil Causes Leukocytes Attraction in the Peritoneal Cavity by Activating Autophagy and HMGB1 Release in Colon Carcinoma Cells. If this drug is used during pregnancy, or if the patient becomes pregnant while using this drug, the patient should be apprised of the potential hazard to the fetus. ; Yang, Z.; Stetson, P.L. Interleukin-6-Deficient Mice Develop Hepatic Inflammation and Systemic Insulin Resistance. . Animal reproduction studies have not been conducted with fluorouracil cream. Measuring Rat Kidney Glomerular Number and Size in Vivo with MRI. Effect of Renal Impairment on the Pharmacokinetics and Tolerability of Capecitabine (Xeloda) in Cancer Patients. Akindele, A.J. Zhang, M.; Fan, Y.; Che, X.; Hou, K.; Zhang, C.; Li, C.; Wen, T.; Wang, S.; Cheng, Y.; Liu, Y.; et al. There was also a significant reduction in the concentration of total proteins obtained from the lung in the treated group (, In the liver tissue, the activity of MPO and NAG and the levels of NO and IL-1 increased significantly after 5-FU treatment. ; Liu, Y.Y. Eurofarma Flusan (Fluorouracila)Bula Para o Profissional Da Sade 2015, 114. The Biological Effects of Interleukin 6. Fluorouracil produced petite mutations in [3] They may include inflammation of the mouth, loss of appetite, low blood cell counts, hair loss, and inflammation of the skin. 5-fluorouracil induced cardiotoxicity: review of the literature. ; Henstridge, D.C.; Watson, N.; Zaffino, L.A.; Babb, J.R.; Boon, J.; Meikle, P.J. or adamantane (8armPEG20k-Ad) and were loaded with 5-fluorouracil (5-FU) and methotrexate (MTX). Efudex (fluorouracil): Skin irritation, burning, redness, dryness, pain, swelling, tenderness, or changes in skin color may occur at the site of application. Karabay CY, Gecmen C, Aung SM, Guler A, Candan O, Batgerel U, Kalayci A, Kirma C. Perfusion. Disclaimer. 5: 1005. : supervision, conceptualization, funding acquisition, writingreviewing and editing, and data curation. Interleukin analyses were performed using enzyme-linked immunosorbent assay (ELISA) kits (R&D Systems) according to the manufacturers protocol. Mari, M.; Morales, A.; Colell, A.; Garca-Ruiz, C.; Kaplowitz, N.; Fernndez-Checa, J.C. Mitochondrial Glutathione: Features, Regulation and Role in Disease. Actikerall (5-Fluorouracil 0.5% and Salicylic Acid 10%) Topical Solution for Patient-directed Treatment of Actinic Keratoses, Consumer medicine information and data sheets, The combination of 5% fluorouracil cream with, Combining low-potency 0.5% fluorouracil cream with 10%. Fluorouracil Topical (5-FU ; Buttow, N.C. Therefore, information on its side effects when administered at a clinically recommended dose is relevant. ; Alqahtani, S.; Jan, B.L. ; Liu, J.H. Fluorouracil 5 topical cream side effects Occleston, N.L. The samples were homogenized and centrifuged for 20 min at 11,000 rpm, 4 C. N.C.B. Persistent or recurrent actinic keratoses can be treated with a further course of fluorouracil cream, imiquimod cream or by cryotherapy. Spermatogonial differentiation was also inhibited by fluorouracil, resulting in transient infertility. The diameter of 100 hepatic sinusoids per animal was also measured. TO OPEN: Remove cap and puncture seal with point on cap. Repopulation of Cancer Cells during Therapy: An Important Cause of Treatment Failure. ; Allen, T.L. Model List of Essential Medicines. Injectable Hydrogels Based on Cyclodextrin/Cholesterol Inclusion Xu, Z.; Li, Z.; Liao, Z.; Gao, S.; Hua, L.; Ye, X.; Wang, Y.; Jiang, S.; Wang, N.; Zhou, D.; et al. 14C-labeled fluorouracil added to a 5% preparation. ; Kode, A. Oxidant and Antioxidant Balance in the Airways and Airway Diseases. Skardal, A.; Murphy, S.V. Macrophage Akt1 Kinase-Mediated Mitophagy Modulates Apoptosis Resistance and Pulmonary Fibrosis. Fluorouracil Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. 1009, Slater Road, ; Sherwood, M.B. Therefore, finding the potential side effects of 5-FU treatment is essential to ameliorate the harmful effects of this treatment in the whole body. WebSide effects of use by injection are common. Fluorouracil Cream USP should be applied preferably with a nonmetal applicator or suitable glove. The aim is to provide a snapshot of some of the Apply preferably with a nonmetal applicator or suitable glove. Make-up can be worn if the reaction is mild, but should be avoided in the case of erosions and ulceration. Bookshelf ; Fonseca, F.L.A. Updated Epidemiology of Gastrointestinal Cancers in East Asia. WebFluorouracil (5FU) | Macmillan Cancer Support Fluorouracil (5FU) is a chemotherapy drug used to treat different cancers including breast, bowel, skin, stomach, oesophageal The reaction was performed using the supernatant with the addition of Tris-HCl EDTA buffer (pH = 7.5) and pyrogallol [, The supernatant of each sample was diluted in 30% methanol. Fluorouracil is also occasionally used to treat the following skin conditions: It works best on face and scalp and is less effective on other body sites. Lipids, Rev. ; Almatroudi, N.M. Myricetin (3,3,4,5,5,7-Hexahydroxyflavone) Prevents 5-Fluorouracil-Induced Cardiotoxicity. Fluorouracil Injection Hosp. The authors declare that they have no known competing financial interest or personal relationships that could have appeared to influence the work reported in this paper. If any conclusions made in the paper depend on a particular dataset then this dataset will be made available to the readers. The https:// ensures that you are connecting to the These raw areas result from the destruction of defective skin cells. Fluorouracil (5-FU): How to Apply & Side Effects Excessive inflammatory reactions to fluorouracil cream PM 2.5 Induced Pulmonary Fibrosis in Vivo and in Vitro. M.d.G.d.S.C. Acta Mol. Chemotherapy induced stroke mimic: 5-Fluorouracil encephalopathy fulfilling criteria for tissue plasminogen activator therapy. Fluorouracil wraps, also known as chemowraps, are an in-office occlusive treatment for extensive field treatment for actinic keratoses and intraepidermal carcinomas. Data are expressed as the mean standard error (parametric) and median lower limit-upper limit (nonparametric), Oxidative Stress and Antioxidant Therapy in Pulmonary Hypertension, Oligomeric Proanthocyanidins: An Updated Review of Their Natural Sources, Synthesis, and Potentials, Pravastatin Prevents Increases in Activity of Metalloproteinase-2 and Oxidative Stress, and Enhances Endothelium-Derived Nitric Oxide-Dependent Vasodilation in Gestational Hypertension, https://www.uicc.org/news/globocan-2020-new-global-cancer-data. ; Smith, D.E. Renal Inhibition of MiR-181a Ameliorates 5-Fluorouracil-Induced Mesangial Cell Apoptosis and Nephrotoxicity. 5 ; Liu, Z.Q. Part of this homogenate was separated for the reduced glutathione (GSH) evaluation. Fluorouracil cream must not be used during pregnancy because it has been shown to cause birth deformities. Evaluation of the Treatment with Resveratrol-Loaded Nanoparticles in Intestinal Injury Model Caused by Ischemia and Reperfusion. Information for Patients: Abuohashish, H.M.; Zaghloul, E.H.; El Sharkawy, A.S.; Abbas, E.M.; Ahmed, M.M. WebFluorouracil may cause side effects. To report SUSPECTED ADVERSE REACTIONS, contact Accord Healthcare Inc. at 1-866-941-7875 and/or FDA at 1-800-FDA-1088 or ; et al. Fluorouracil, including Fluorouracil cream may be fatal if ingested by pets. Sometimes fluorouracil cream is prescribed in combination with another topical agent. OR INTRAVAGINAL USE. Relationships Between Organ Weight and Body/Brain Weight in the Rat: WhaT Is the Best Analytical Endpoint? ; Dongsar, T.S. Solar keratoses which do not respond should be biopsied to confirm the diagnosis. (2020) [, The internal and external areas of both the proximal and distal tubules were also measured, and the thickness of each tubule was calculated by subtracting the external area from the internal area (external area internal area = thickness). In the human body, organs and tissues work together and are highly connected through complex interactions [. allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue Sommer, J.; Mahli, A.; Freese, K.; Schiergens, T.S. Differentiating stroke mimics is crucial as recombinant tissue plasminogen activator therapy should be given within a 4.5 hours window after an ischemic stroke. those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). Fluorouracil Topical: MedlinePlus Drug Information Carcinogenesis, Mutagenesis, Impairment of Fertility: ; Mendoza-Gamboa, E.; Prado-Garca, H.; Rivera-Morales, L.G. PMC Unable to load your collection due to an error, Unable to load your delegates due to an error. AlDosari, S.M. Pregnancy:Teratogenic Effects ; Zhang, L.; Xu, W.; Wong, S.H. WebThis side effects happens in fewer than 1 in 100 people (fewer than 1%). ; de Souza Pimentel, P.V. We also detected elevated levels of inflammatory markers, histological lesions, apoptotic cells, and aspartate aminotransferase. Nigam, S.; Schewe, T. Phospholipase A2s and Lipid Peroxidation. The clinical protocol of 5-FU promotes toxicity in the liver, kidneys, and lungs of healthy rats, resulting in different levels of histological and biochemical alterations. Cerebral vasospasm with associated transient ischemia is a rare but significant adverse effect of the 5-FU. Protective Effect of Carvedilol Alone and Coadministered with Diltiazem and Prednisolone on Doxorubicin and 5-Fluorouracil-Induced Hepatotoxicity and Nephrotoxicity in Rats. ; Gupta, N.; Almalki, W.H. Pediatric Use: In an additional study, negligible amounts of labeled material were found in plasma, urine, and expired CO It takes two to four weeks for healthy new skin to replace the sun-damaged skin destroyed by the fluorouracil cream. Irritation may last for 2 weeks or longer after you stop using this drug. The area will look worse than before treatment, which will likely continue for a few weeks after treatment stops. ; Tarnuzzer, R.W. TUNEL is a dUTP-mediated cutting-edge labeling assay, and the reagents in the kit allow the labeling of the 3OH terminus of the free (exposed) DNA. ; et al. https://doi.org/10.3390/antiox12051005, da Silva MC, Fabiano LC, da Costa Salomo KC, de Freitas PLZ, Neves CQ, Borges SC, de Souza Carvalho MdG, Breithaupt-Faloppa AC, de Thomaz AA, dos Santos AM, Buttow NC. Tong, Z.; Cheng, M.; Yu, Y.; Yu, J.; Yin, Y.; Liu, J.; Zhang, S.; Jiang, S.; Dong, M. Correlation between Pharmacokinetic Parameters of 5-Fluorouracil and Related Metabolites and Adverse Reactions in East-Asian Patients with Advanced Colorectal Cancer. most exciting work published in the various research areas of the journal. Fluorouracil Cream USP is topical preparations containing the fluorinated pyrimidine 5-fluorouracil, an antineoplastic antimetabolite. NOT FOR OPHTHALMIC, ORAL, ; et al. Jimnez, R.; Hijona, E.; Emparanza, J.; Alstiza, J.M. J Clin Invest. Fluorouracil cream should not be used in patients with dihydropyrimidine dehydrogenase (DPD) enzyme deficiency. A Rodent Model of Human-Dose-Equivalent 5-Fluorouracil: Toxicity in the Liver, Kidneys, and Lungs. ; de Freitas, A.P.F. Actinic or Solar Keratosis: Australas J Dermatol. eCollection 2021 Sep 14. ; Zhang, H.; Guo, Y.; Han, B.; Jiang, P. The Intestinal Redox System and Its Significance in Chemotherapy-Induced Intestinal Mucositis. A diagnostic challenge. The topical application of the 5% cream to rats yielded an LD If fluorouracil cream is applied with the fingers, the hands should be washed immediately afterward. 2013 Nov;54(4):3136. Arrange for your dermatologist, family doctor, or skin cancer nurse to review you during treatment to check on progress and to determine how long to continue using fluorouracil cream. Keep it off the lips, unless specifically instructed to use it on this site. https://www.cancer.gov/research/areas/global-health#:~:text=Challenges%20in%20Global%20Cancer%20Research,-Addressing%20the%20rising&text=Drugs%20and%20vaccines%20are%20sometimes,less%20effective%20and%20more%20costly. FLUOROURACIL- fluorouracilcream Keep it locked up so other people cannot mistakenly use it to treat a rash. ; Carter, A.B. Nishikawa, Y.; Funakoshi, T.; Horimatsu, T.; Miyamoto, S.; Matsubara, T.; Yanagita, M.; Nakagawa, S.; Yonezawa, A.; Matsubara, K.; Muto, M. Accumulation of Alpha-Fluoro-Beta-Alanine and Fluoro Mono Acetate in a Patient with 5-Fluorouracil-Associated Hyperammonemia. Assayag, M.; Rouvier, P.; Gauthier, M.; Costel, G.; Cluzel, P.; Mercadal, L.; Deray, G.; Isnard Bagnis, C. Renal Failure during Chemotherapy: Renal Biopsy for Assessing Subacute Nephrotoxicity of Pemetrexed. These include burning, crusting, allergic contact dermatitis, pruritus, scarring, rash, soreness, and ulceration. WebIntroduction: 5-Fluorouracil (5-FU) for prophylactic treatment of diffuse actinic keratosis results in an exuberant inflammatory reaction, contributing to patient noncompliance and dissatisfaction.Design: This 5-week split-faced, double-blind, randomized controlled trial involved 30 subjects with diffuse facial AK who received twice daily 5-FU treatment for 2 ; Da Costa, K.C. Fluorouracil cream is applied once or twice a day after washing with plain water. The rats were acclimated to standard laboratory conditions with a light/dark cycle of 12 h and a temperature of 22 1 C. Therefore, the localized delivery of chemotherapy helps to overcome such a problem. WebFluorouracil (5-FU) is a commonly used chemotherapeutic agent in many cancers. Since DNA and RNA are essential for cell division and growth, the effect of fluorouracil may be to create a thymine deficiency which provokes unbalanced growth and death of the cell. 5-Fluorouracil (5-FU) is a chemotherapy drug widely used to treat a range of cancer types, despite the recurrence of adverse reactions. Koseki, J.; Matsui, H.; Konno, M.; Nishida, N.; Kawamoto, K.; Kano, Y.; Mori, M.; Doki, Y.; Ishii, H. A Trans-Omics Mathematical Analysis Reveals Novel Functions of the Ornithine Metabolic Pathway in Cancer Stem Cells. 2023; 12(5):1005. Longer may be necessary for the treatment of squamous cell carcinoma in situ. Gelen, V.; engl, E.; Yldrm, S.; Senturk, E.; Tekin, S.; Kkrt, A. CLINICAL PHARMACOLOGY) Novel Strategies to Improve the Anticancer Action of 5-Fluorouracil by Using Drug Delivery Systems. Available online: de Miranda, J.A.L. The results were expressed in m, The number of renal corpuscles in the cortex was quantified in 50 random fields per animal. Use of fluorouracil cream in dermatology, 387172005, 326860000, 292234002, 713977002, 375521000, Fluorouracil wraps, also known as chemowraps, are an in-office. Yu, Q.Q. 2018 Mar 1;17(3):274-280. Biological Physics and Cell Signaling Laboratory, Institute of Biology, Department of Structural and Functional Biology, State University of Campinas, Campinas 13083-970, SP, Brazil, Department of Morphological Science, State University of Maring, Maring 87020-900, PR, Brazil, Departament of Biological Science, State University of Santa Cruz, Ilhus 45662-900, BA, Brazil, Laboratrio de Cirurgia Cardiovascular e Fisiopatologia da Circulao (LIM-11), Instituto do Corao (InCor), Faculdade de Medicina da Universidade de So Paulo, So Paulo 01246-904, SP, Brasil, Quantum Electronic Department, Institute of Physics Gleb Wataghin, State University of Campinas, Campinas 13083-872, SP, Brazil. Occlusion of the skin with resultant hydration has been shown to increase percutaneous penetration of several topical preparations. (, To evaluate the impact of 5-FU treatment in the cell death by apoptosis, TUNEL reaction was performed (, The measurements of the oxidative parameters in the liver showed that treatment with 5-FU induced a significant reduction in the activity of CAT and GST enzymes and in the levels of GSH; however, the activity of SOD was not changed between the groups (, The analysis of the kidney tissue showed a significant increase in the enzymatic activity of CAT and SOD in the treated group. If any occlusive dressing is used in treatment of basal cell carcinoma, there may be an increase in the severity of inflammatory reactions in the adjacent normal skin. Su, L.; Zhang, J.; Gomez, H.; Kellum, J.A. There are no adequate and well-controlled studies in pregnant women with either the topical or the parenteral forms of fluorouracil. These results will be useful in the search for new adjuvants to attenuate the adverse effects of 5-FU in such organs. Treated skin should normally be very carefully protected from the sun; stay indoors during the middle part of the day. The Griess reaction was used to indirectly evaluate NO from its by-product, nitrite [. Doses of 125 to 250 mg/kg, administered intraperitoneally, have been shown to induce chromosomal aberrations and changes in chromosome organization of spermatogonia in rats. Similarly, intraperitoneal doses of 12 to 37 mg/kg given to rats between Days 9 and 12 of gestation and intramuscular doses of 3 to 9 mg/kg given to hamsters between Days 8 and 11 of gestation were teratogenic and/or embryotoxic (i.e., resulted in increased resorptions or embryolethality). the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, Management of Chemotherapy-Associated Hepatotoxicity in Colorectal Liver Metastases. Epub 2020 Sep 9. WebSide-effects For fluorouracil General side-effects: Common or very common Alopecia; diarrhoea; mucositis; nausea; neutropenia; skin reactions; stomatitis; thrombocytopenia; UniveRsitRio Pedro Ernesto UeRJ. Therapy may be required for as long as 10 to 12 weeks before the lesions are obliterated.
5 fluorouracil side effects
5 fluorouracil side effects
5 fluorouracil side effects